Ro 41-1049 hydrochloride
规格
| Cas Number | 127917-66-2 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 32 mg/mL (106.04 mM) H2O : 25 mg/mL (82.84 mM; Need ultrasonic) |
| 过滤标签 | Monoamine Oxidase,神经元信号传导 |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | Ro 41-1049 盐酸盐是一种可逆的单胺氧化酶-A（MAO-A）选择性抑制剂。在人类额叶皮层和胎盘的膜制备物中发现了与 [ 3 H]Ro 41-1049 高亲和力结合位点的同质群体（K d |
| 英文描述 |
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A) . An homogeneous population of high affinity binding sites for [ 3 H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta ( K d values of 16.5 and 64.4 nM, respectively) In Vivo Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats (200-240 g)Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg Administration: Intraperitoneal injection; for 3 hours Result: Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA. Form:Solid IC50& Target:MAO-A |