RP-64477
规格
| Cas Number | 135239-65-5 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (200.51 mM); Water: Insoluble; Ethanol: Insoluble; |
| 简短描述 | 酰基转移酶抑制剂 |
| 英文简短描述 | Acyltransferase Inhibitors |
| 过滤标签 | Acyltransferase,Metabolic Enzyme/Protease |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | RP-64477 是胆固醇酯化酶酰辅酶 A：胆固醇 O-酰基转移酶（ACAT）的强效抑制剂。在人肠道（CaCo-2）、肝脏（HepG2）和单核细胞（THP-1）细胞试验中，RP-64477 抑制 ACAT 活性的 IC50 分别为 113 nM、503 nM 和 180 nM。 |
| 英文描述 |
Information RP-64477 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) . RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively. Targets ACAT (CaCo-2 cell-based assay); ACAT (THP-1 cell-based assay); ACAT (HepG2 cell-based assay) 113 nM; 180 nM; 503 nM |