RRD-251盐酸盐
规格
| Cas Number | 72214-67-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Soluble in DMSO: >10 mg/mL and Water: >2 mg/mL |
| 简短描述 | Rb / Raf-1相互作用的可逆选择性干扰剂 |
| 英文简短描述 | a reversible selective disruptor of Rb/Raf-1 interaction |
| 过滤标签 | Apoptosis,Raf,MAPK/ERK Pathway |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 描述 |
RRD-251盐酸盐是Rb / Raf-1相互作用的可逆，有效和选择性破坏剂。视网膜母细胞瘤抑癌蛋白（Rb）通过抑制E2F转录因子家族的转录活性来控制G1-S边界。Raf-1激酶在G1期早期与Rb结合并使其磷酸化。RRD-251在体内以Rb依赖性方式显着抑制血管生成和肿瘤生长。RRD-251不会抑制B-Raf与Rb的结合以及Raf-1与Mek1 / 2的结合。同样，RRD-251不会影响与细胞周期蛋白D，细胞周期蛋白E或Raf-1相关的激酶活性。 |
| 英文描述 |
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1. |