SR-318
规格
| Cas Number | 2413286-32-3(DMSO) |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Apoptosis,TNF Receptor,p38 MAPK,MAPK/ERK Pathway,Compound libraries |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 物理形态 | 液体 |
| 生化和生理学机理 | SR-318 是一种强效、高选择性 p38 MAPK 抑制剂，对 p38α、p38β 和 p38α/β 的 IC 50 s 分别为 5 nM、32 nM 和 6.11 μM。SR-318 能有效抑制全血中 TNF-α 的释放，IC 50 为 283 nM。SR-318具有抗癌和抗 |
| 英文描述 |
SR-318 is a potent and highly selective p38 MAPK inhibitor with IC 50 s of 5 nM, 32 nM and 6.11 μM for p38α , p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC 50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity In Vitro SR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:p38α 5 nM (IC 50 ) p38β 32 nM (IC 50 ) |