SAR7334
规格
| Cas Number | 1333210-07-3 |
| 规格或纯度 | Moligand™, ≥97% |
| 级别 | Moligand™ |
| 纯度 | ≥97% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| Action Type | 通道阻滞剂 |
| Mechanism Of Action | TRPC3 通道阻断剂;TRPC6 通道阻断剂;TRPC7 通道阻断剂 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 74 mg/mL (201.15 mM); Ethanol: 74 mg/mL (201.15 mM); Water: Insoluble; |
| 简短描述 | TRP 通道抑制剂 |
| 英文简短描述 | TRP Channel Inhibitors |
| 过滤标签 | TRPC3 Channel blocker,TRPC6 Channel blocker,TRPC7 Channel blocker,TRP Channel,神经元信号传导,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | SAR7334 是一种新型、高效力和生物可利用性的 TRPC6 通道抑制剂。在膜片钳实验中，SAR7334 阻断 TRPC6 电流的 IC50 为 7.9 nM。 |
| 描述 |
|
| 英文描述 |
Information SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment. Targets TPRC6 (Cell-free assay) 7.9nM In vitro SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. In vivo Pharmacokinetic studies of SAR7334 demonstrates that the compound was suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR). Cell Research(from reference) Cell lines：HEK cells |