SB 699551 dihydrochloride
规格
| Cas Number | 864741-95-7 |
| 规格或纯度 | ≥96% |
| 纯度 | ≥96% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 别名 | N-[2-(二甲基氨基)乙基] -N-[[4'-[[(2-苯基乙基)氨基]甲基] [1,1'-联苯基] -4-基]甲基]环戊烷丙酰胺二盐酸盐 |
| 品牌 | 阿拉丁 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 14.62, 最高浓度(mM): 25；溶于ethanol, 最高浓度 (mg/mL): 5.85, 最高浓度(mM): 10 |
| 简短描述 | 选择性5-HT5拮抗剂 |
| 英文简短描述 | Selective 5-ht5aantagonist |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 选择性5-ht5受体拮抗剂（5-ht5a，5-HT1B / D，5-HT2A，5-HT2C，5-HT1A和5-HT7受体的pKi值分别为8.3，<6.0，<6.0，<6.0，<5.5，<5.5 ）。SB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride).[2] It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor. SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A. |
| 英文描述 |
SB 699551 dihydrochloride has been used to identify the antagonism of 5-HT2AR in cell culture-derived hepatitis C virus (HCVcc).
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