Small Cardioactive Peptide B (SCPB)
规格
| Cas Number | 84746-43-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | H2O : 50 mg/mL (43.81 mM; Need ultrasonic) |
| 过滤标签 | Adenylate Cyclase,GPCR/G Protein |
| 储存温度 | 避光,干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 小心肌活性肽 B（SCP B）是一种神经活性肽，可刺激心脏和鳃组织微粒馏分中腺苷酸环化酶的活性，其 EC 50 s 分别为 0.1 和 1.0 μM。 |
| 英文描述 |
Small Cardioactive Peptide B (SCP B ), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC 50 s of 0.1 and 1.0 μM, respectively. In Vitro Small cardioactive peptide B (SCP B ) is a neurally active peptide endogenous to Aplysia . Small cardioactive peptide B (SCP B ) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP B ) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP B ) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP B ) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP B ) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC 50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP B ) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC 50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP B )is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP B ) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC 50 of 0.1 and 1.0μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues) |