SP-96
规格
| Cas Number | 2682114-54-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 91 mg/mL (200.67 mM); Ethanol: 2 mg/mL (4.41 mM); Water: Insoluble; |
| 简短描述 | Aurora B 选择性抑制剂 |
| 英文简短描述 | Aurora B Selective Inhibitors |
| 过滤标签 | 表观遗传学,Aurora Kinase,Cell Cycle/DNA Damage |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | SP-96 是 Aurora B 的一种强效、选择性和非ATP 竞争性抑制剂，IC50 为 0.316 nM。SP-96 可用于三阴性乳腺癌（TNBC）的研究。 |
| 英文描述 |
Information SP-96 is a potent, selective and non-ATP-competitive inhibitor ofAurora Bwith IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC). Targets Aurora B (Cell-free assay) 0.316 nM In vitro SP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line. Cell Research(from reference) Cell lines：MCF-7 cells Incubation Time：24 h |