SRS11-92
规格
| Cas Number | 1467047-25-1 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg 或 200mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 70 mg/mL (198.59 mM); Ethanol: 70 mg/mL (198.59 mM); Water: Insoluble; |
| 简短描述 | 铁死亡抑制剂 |
| 英文简短描述 | Ferroptosis Inhibitors |
| 过滤标签 | Apoptosis,Ferroptosis |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | SRS11-92 (AA9) 是一种铁前列素-1（Fer-1）类似物，是一种强效的铁变态反应抑制剂。SRS11-92 可抑制 Erastin 在 HT-1080 人纤维肉瘤细胞中诱导的铁突变细胞死亡，EC50 为 6 nM。 |
| 描述 |
SRS11-92 是一种铁死亡抑制剂和 Ferrostatin-1 的衍生物。它抑制 Erastin 诱导的 HT-1080 人纤维肉瘤细胞铁致细胞死亡，EC50为6 nM。 |
| 英文描述 |
Information SRS11-92 SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis . SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM. Targets HT-1080 ferroptotic cell death (Cell-based assay) 6 nM(EC50) In vitro SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts. Cell Research(from reference) Cell lines：murine I154F FRDA fibroblasts Concentrations：50 μM to 500 nM Incubation Time：48 h |