Tetramethylcurcumin
规格
| Cas Number | 52328-97-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (235.58 mM; Need ultrasonic) |
| 英文简短描述 | Phenols |
| 过滤标签 | STAT,JAK/STAT Signaling,Stem Cell/Wnt,Phenols |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | 从姜黄素中提取的四甲基姜黄素（FLLL31）可选择性地与 Janus 激酶 2 和 STAT3 Src 同源-2 结构域结合，从而特异性地抑制 STAT3 的磷酸化。四甲基姜黄素具有抗炎和抗癌作用 |
| 英文描述 |
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects In Vitro Tetramethylcurcumin (FLLL31; 2.5 and 5 µM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:STAT3 |