ThioLox
规格
| Cas Number | 1202193-89-2 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (364.46 mM; ultrasonic and warming and heat to 60°C) |
| 过滤标签 | Lipoxygenase,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | ThioLox 是一种竞争性 15-Lipoxygenase-1 （15-LOX-1）抑制剂，其 K i 为 3.30 μM。ThioLox 具有抗炎和保护神经的特性。 |
| 英文描述 |
ThioLox is a competitive 15-lipoxygenase-1 ( 15-LOX-1 ) inhibitor with a K i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties In Vitro ThioLox shows competitive inhibition thus indicating non-covalent interaction with the active site of the 15-LOX-1. ThioLox (50 μM; 24 h) inhibits interleukin (IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS) expression in precision-cut lung slices (PCLS). ThioLox (10 μM; 16 h) prevent lipid peroxidation and mitochondrial superoxide formation in neuronal cells. ThioLox (5-20 μM; 14-16 h) protects HT-22 cells against glutamate toxicity and significantly reduces neuronal cell death. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: Precision-cut lung slices (PCLS) Concentration: 1, 5, 10, 25 and 50 μM Incubation Time: In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h. Result: Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM. Cell Viability AssayCell Line: Neuronal HT-22 cells Concentration: 5, 10 and 20 μM Incubation Time: 14-16 h Result: Significantly reduced neuronal cell death against glutamate toxicity. In Vivo ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 3.30 μM (15-LOX-1) |