Topoisomerase I inhibitor 8
规格
| Cas Number | 210346-40-0 |
| 规格或纯度 |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | Topoisomerase,Cell Cycle/DNA Damage |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 拓扑异构酶 I 抑制剂 8 是一种强效的拓扑异构酶 I 抑制剂。拓扑异构酶 I 抑制剂 8 是喜树碱的六环类似物，对肿瘤细胞具有细胞毒性作用。 |
| 英文描述 |
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells In Vitro Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC 50 s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively. Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC 50 of compound/IC 50 of SN-38=0.51. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Topoisomerase I |