UK-371804 HCl
规格
| Cas Number | 256476-36-5 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | 丝氨酸蛋白酶抑制剂 |
| 英文简短描述 | Serine Protease Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | UK-371804 是一种强效的选择性尿激酶型纤溶酶原激活剂（uPA）抑制剂，具有出色的酶效力（Ki=10 nM）和选择性（与 tPA 相比为 4000 倍，与 plasmin 相比为 2700 倍）。 |
| 英文描述 |
Information UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Targets uPA (Cell-free assay) 10 nM(Ki) In vitro UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM). In vivo in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. |