Verubecestat (MK-8931) Trifluoroacetate
规格
| Cas Number | 2095432-65-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 250mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 81 mg/mL (154.74 mM); Ethanol: 5 mg/mL (9.55 mM); Water: Insoluble; |
| 简短描述 | BACE抑制剂 |
| 英文简短描述 | BACE Inhibitors |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 韦鲁贝斯特（MK-8931）三氟乙酸酯是一种强效的选择性β-分泌酶抑制剂和BACE1蛋白抑制剂或β位点APP分解酶1抑制剂。 |
| 描述 |
Verubecestat (MK-8931) Trifluoroacetate是一种有效的、选择性的beta-分泌酶的抑制剂、BACE1抑制剂。 |
| 英文描述 |
Information Verubecestat (MK-8931) Trifluoroacetat Verubecestat (MK-8931) Trifluoroacetat is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Targets BACE2 (Cell-free assay); BACE1 (Cell-free assay) 0.37 nM(Ki); 1.75 nM(Ki) In vitro Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. In vivo Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing. |