VT104
规格
| Cas Number | 2417718-25-1 |
| 规格或纯度 |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | YAP,Stem Cell/Wnt |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | VT104 是一种强效的口服活性 YAP/TAZ 抑制剂。VT104 可阻止内源性 TEAD1 和 TEAD3 蛋白的棕榈酰化。VT104 可用于癌症研究。 |
| 英文描述 |
VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer. In Vitro VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NCI-H226-tumor bearing mice Dosage: 0.3, 1, and 3 mg/kg Administration: Oral administration Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner. Form:Solid |