XL01126
规格
| Cas Number | X658669 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 1mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 100 mg/mL (98.07 mM) |
| 过滤标签 | 羟基聚乙二醇,PROTACs,Autophagy,LRRK2,PROTAC,PROTAC linker,DBCO PEG,Aliphatic Linkers |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 英文描述 |
XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-c Appearance:Solid IC50& Target:DC50: 15-72 nM (LRRK2) In Vitro:XL01126 (300 nM; 4 h) exhibits strong degradation performance by forming a positively cooperative ternary complex with E3 ubiquitin ligase ligand VHL and target protein LRRK2. XL01126 (10, 30, 100 nM; 24 h) increases mitophagy in immortalized mouse e In Vivo:XL01126 (30mg/kg; p.o.; single dose) shows oral activity with bioavailable value (F) of 15% and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Pharmacokinetic property of XL01126 in miceRoute Dose mg/kg) Biological Activity:XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research . XL01126 exerts function of study of non- |