YM17E
规格
| Cas Number | 124900-72-7 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 1mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : ≥ 125 mg/mL (191.45 mM) |
| 过滤标签 | Acyltransferase,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | YM17E 是酰基 CoA：胆固醇酰基转移酶（ACAT）的抑制剂，在体外兔肝微粒体中的 IC 50 为 44 nM。 |
| 英文描述 |
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase ( ACAT ), with IC 50 of 44 nM in rabbit liver microsomes in vitro. In Vitro YM17E is as potent in inhibiting ACAT activity in the liver as in the intestine, with IC 50 values of 45 and 34 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125 I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration . YM17E inhibits production of [ 14 C]cholesteryloleate from [ 14 C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 44 nM (ACAT in rabbit liver microsomes) |