YLF-466D
规格
| Cas Number | 1273323-67-3(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | 表观遗传学,AMPK,PI3K/Akt/mTOR,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | YLF-466D 是一种新开发的 AMPK 激活剂，可抑制血小板聚集。 |
| 英文描述 |
YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation. In Vitro The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC 50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:AMPK |