ZZL-7
规格
| Cas Number | 99141-91-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 250 mg/mL (1023.37 mM; Need ultrasonic) |
| 过滤标签 | Serotonin Transporter,神经元信号传导 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | ZZL-7 是一种速效抗抑郁剂。ZZL-7 通过干扰背侧剑突核（DRN）中的血清素转运体（SERT）和神经元一氧化氮合酶（nNOS）之间的相互作用而发挥作用。ZZL-7 可轻易穿过血脑屏障。ZZ |
| 英文描述 |
ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD). In Vitro ZZL-7 (1.0 μM; or 2 h) incubation of the cultured 293T cells transfected with nNOS and SERT, significantly decreases the SERT-nNOS complex level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time . Intragastric administration of ZZL-7 (10, 20, and 40 mg/kg; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment . ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SERT-Cre mice Dosage: 10 mg/kg Administration: i.p.; once Result: Significantly increased firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. Form:Oil |